Tutorial for KlaSig shiny app

KlaSig is a computational R shiny application for predicting the prognosis of lung adenocarcinoma (The article is currently under review). Through this app, you can view the Kla.Sig scores we calculated for 10 LUAD cohorts, along with their survival curves and ROC curves. Additionally, you can upload your own LUAD RNA-seq data to compute Kla.Sig scores and perform prognostic evaluation. Below is a simple tutorial for using this app.

Step 1. Download the R shiny app to your local PC

Users can download the KlaSig app to their local computer for use via the following code.

git clone https://github.com/A-Oncol/KlaSig

Note: Please remember the path of your working directory when you download. For example, I am currently executing the download command in C:/Users/Ao Shen/Desktop, so the downloaded app are located in C:/Users/Ao Shen/Desktop/KlaSig.

Step 2. Run KlaSig app on your local PC

Open your local Rstudio software, and run the following R codes.

# install.packages("shiny")
library(shiny)
your_KlaSig_path <- "path/to/your/downloaded/KlaSig"  # Setting to your own directory path as the above noted.
runApp(your_KlaSig_path)

Note: If prompted to install certain required R packages while running this app, simply download and install them according to the respective package's installation instructions.

Now you can view or calculate the LUAD's Kla.Sig score.