diff --git a/sqlx-core/src/common/statement_cache.rs b/sqlx-core/src/common/statement_cache.rs
index eb800ca623..0aad15354a 100644
--- a/sqlx-core/src/common/statement_cache.rs
+++ b/sqlx-core/src/common/statement_cache.rs
@@ -72,4 +72,8 @@ impl<T> StatementCache<T> {
     pub fn is_enabled(&self) -> bool {
         self.capacity() > 0
     }
+
+    pub fn iter(&self) -> impl Iterator<Item=&T> {
+        self.inner.iter().map(|(_, v)| v)
+    }
 }
diff --git a/sqlx-mysql/src/connection/executor.rs b/sqlx-mysql/src/connection/executor.rs
index 2b660b94b3..071ca8b95e 100644
--- a/sqlx-mysql/src/connection/executor.rs
+++ b/sqlx-mysql/src/connection/executor.rs
@@ -183,7 +183,11 @@ impl MySqlConnection {
             loop {
                 // query response is a meta-packet which may be one of:
                 //  Ok, Err, ResultSet, or (unhandled) LocalInfileRequest
-                let mut packet = self.inner.stream.recv_packet().await?;
+                let mut packet = self.inner.stream.recv_packet().await.inspect_err(|_| {
+                    // if a prepared statement vanished on the server side, we get an error here
+                    // clear the statement cache in case the connection got reset to cause re-preparing
+                    self.inner.cache_statement.clear();
+                })?;
 
                 if packet[0] == 0x00 || packet[0] == 0xff {
                     // first packet in a query response is OK or ERR
diff --git a/sqlx-mysql/src/connection/mod.rs b/sqlx-mysql/src/connection/mod.rs
index 569ad32722..d5a23603e3 100644
--- a/sqlx-mysql/src/connection/mod.rs
+++ b/sqlx-mysql/src/connection/mod.rs
@@ -57,6 +57,19 @@ impl MySqlConnection {
             .status_flags
             .intersects(Status::SERVER_STATUS_IN_TRANS)
     }
+
+    pub async fn nuke_cached_statements(&mut self) -> Result<(), Error> {
+        for (statement_id, _) in self.inner.cache_statement.iter() {
+            self.inner
+                .stream
+                .send_packet(StmtClose {
+                    statement: *statement_id,
+                })
+                .await?;
+        }
+
+        Ok(())
+    }
 }
 
 impl Debug for MySqlConnection {
diff --git a/tests/mysql/mysql.rs b/tests/mysql/mysql.rs
index 5d6a5ef233..fb07657bdc 100644
--- a/tests/mysql/mysql.rs
+++ b/tests/mysql/mysql.rs
@@ -54,6 +54,30 @@ async fn it_maths() -> anyhow::Result<()> {
     Ok(())
 }
 
+#[sqlx_macros::test]
+async fn it_clears_statement_cache_on_error() -> anyhow::Result<()> {
+    setup_if_needed();
+
+    let query = "SELECT 1";
+
+    let mut conn = new::<MySql>().await?;
+    let _ = sqlx::query(query).fetch_one(&mut conn).await?;
+    assert_eq!(1, conn.cached_statements_size());
+
+    // clear cached statements only on the server side
+    conn.nuke_cached_statements().await?;
+    assert_eq!(1, conn.cached_statements_size());
+
+    // one query fails as the statement is not cached server-side any more, client-side cache is cleared
+    assert!(sqlx::query(query).fetch_one(&mut conn).await.is_err());
+    assert_eq!(0, conn.cached_statements_size());
+
+    // next query succeeds again
+    let _ = sqlx::query(query).fetch_one(&mut conn).await?;
+
+    Ok(())
+}
+
 #[sqlx_macros::test]
 async fn it_can_fail_at_querying() -> anyhow::Result<()> {
     let mut conn = new::<MySql>().await?;