About

The Cell Cycle Browser (CCB) is an interactive tool for exploring, simulating, and perturbing the human cell cycle. It was developed in the spirit of the UCSC Genome Browser, which provides a graphical view of genome sequence data along the physical coordinates of the chromosomes (https://genome.ucsc.edu). Unlike the Genome Browser, however, the primary axis of the CCB browser is time. In its most basic functionality, the CCB displays time series data representing various molecular activities over the course of a single cell cycle. Single-cell traces from time-lapse fluorescent microscopy experiments—representing different biological activities from multiple cell lines—may be aligned in time to examine the temporal sequence of cell cycle events.

Contributors

• David Borland: Lead Programmer, User Interface
• Hong Yi: Lead Programmer, Server Support and Model Simulation
• Gavin Grant: Postdoctoral Fellow, Biosensor Design and Microscopy
• Kasia Kedziora: Postdoctoral Fellow, Microscopy and Image Analysis
• Sherry Chao: Graduate Student, Microscopy and Image Analysis
• Ray Haggerty: Graduate Student, Logo Design
• Jayashree Kumar: Graduate Student, Generation of SBML Models
• Sam Wolff: Senior Scientist, Live-Cell Microscopy
• Jean Cook: Principal Investigator
• Jeremy Purvis: Principal Investigator

This work was supported by a medical research grant from W. M. Keck Foundation.

To learn the full suite of functionalities of the tool, follow along in this Cell Cycle Browser Tutorial.

Version number: v1.0

---

The Cell Cycle Browser has been tested with:

• Chrome v66.0.3359.139
• Firefox v59.0.3
• Safari v11.1